PGCA (Cleaved-Ala17) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES19949-50, ES19949-100

Citations, Manuals and MSDS Available upon request.

Background: alternative products:Additional isoforms seem to exist, developmental stage:Expression was detected in chondrocytes throughout the developing skeleton., disease:Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy., domain:Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3., function:This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region., online information:Aggrecan, PTM:Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase., similarity:Belongs to the aggrecan/versican proteoglycan family., similarity:Contains 1 C-type lectin domain., similarity:Contains 1 EGF-like domain., similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain., similarity:Contains 1 Sushi (CCP/SCR) domain., similarity:Contains 4 Link domains., subunit:Interacts with FBLN1., tissue specificity:Restricted to cartilages.,

Alternate Name: Aggrecan core protein (Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Rat

Immunogen: Synthesized peptide derived from human PGCA (Cleaved-Ala17)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 240-260kD

Human SWISS Prot NO: P16112

Subcellular Location: Secreted, extracellular space, extracellular matrix.

Research Use Only