MMP19 (Cleaved-Tyr98) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20024-50, ES20024-100

Citations, Manuals and MSDS Available upon request.

Background: alternative products:Additional isoforms seem to exist, catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site., cofactor:Binds 1 zinc ion per subunit., cofactor:Calcium., disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient., function:Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin., PTM:Activated by autolytic cleavage after Lys-97., similarity:Belongs to the peptidase M10A family., similarity:Contains 4 hemopexin-like domains., tissue specificity:Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.,

Alternate Name: Matrix metalloproteinase-19 (MMP-19; EC 3.4.24.-; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18)

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 45 55kD

Human Gene ID: 4327

Human SWISS Prot NO: Q99542

Subcellular Location: Secreted, extracellular space, extracellular matrix.

Research Use Only