MMP8 (Cleaved-Leu101) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20030-50, ES20030-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I., cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 3 calcium ions per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Cannot be activated without removal of the activation peptide., function:Can degrade fibrillar type I, II, and III collagens., similarity:Belongs to the peptidase M10A family., similarity:Contains 4 hemopexin-like domains., subcellular location:Stored in intracellular granules., tissue specificity:Neutrophils.,

Alternate Name: Neutrophil collagenase (EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL)

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human MMP8 (Cleaved-Leu101)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 40 53kD

Human Gene ID: 4317

Human SWISS Prot NO: P22894

Subcellular Location: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Stored in intracellular granules.

Research Use Only