AMPKα1 (phospho-Ser485) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES18372-50, ES18372-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],

Alternate Name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)

Source: Rabbit

Applications: WB

Dilution: WB 1:1000-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized phosho peptide around human AMPKα1 (Ser485)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 65kD

Human Gene ID: 5562

Human SWISS Prot NO: Q13131

Subcellular Location: Cytoplasm. Nucleus. In response to stress, recruited by p53/TP53 to specific promoters.

Research Use Only